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Thank you for your interest in Bioelectronic Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

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  1. Previous efforts to translate vagus nerve stimulation (VNS) therapies from preclinical studies to human clinical applications (e.g., for stroke, heart failure, and inflammatory diseases) did not account for in...

    Authors: Eric D. Musselman, Ishani Raha, Nicole A. Pelot and Warren M. Grill
    Citation: Bioelectronic Medicine 2025 11:11
    Content type: Research Published on:

  2. Over a third of the global population is affected by obesity, fatty liver disease (Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD), and its severe form, MASH (Metabolic Dysfunction-Associated ...

    Authors: Sahara John, Krishanu Bhowmick, Andrew Park, Hai Huang, Xiaochun Yang and Lopa Mishra
    Citation: Bioelectronic Medicine 2025 11:10
    Content type: Review Published on:

  3. Preclinical and early clinical evidence demonstrates that electrical stimulation (ES) applied for one hour following surgical nerve intervention enhances axonal regeneration and functional outcomes. Wide clini...

    Authors: Christopher J Coroneos, Carolyn Levis, Michael P Willand, Katelyn JW So and James R Bain
    Citation: Bioelectronic Medicine 2025 11:9
    Content type: Research Published on:

  4. Low intensity, trans-spinal focused ultrasound (tsFUS) is a noninvasive neuromodulation approach that has been shown to modulate spinal circuit excitability in healthy rats. Here, we evaluated the potential of...

    Authors: Weiguo Song, Alice Giannotti, Alexandra Bekiaridou, Ona Bloom and Stavros Zanos
    Citation: Bioelectronic Medicine 2025 11:8
    Content type: Brief Report Published on:

  5. Temporal interference (TI) is a method of non-invasive brain stimulation using transcutaneous electrodes which allows the targeting and modulation of deeper brain structures, not normally associated with non-i...

    Authors: Boris Botzanowski, Emma Acerbo, Sebastian Lehmann, Sarah L. Kearsley, Melanie Steiner, Esra Neufeld, Florian Missey, Lyle Muller, Viktor Jirsa, Brian D. Corneil and Adam Williamson
    Citation: Bioelectronic Medicine 2025 11:7
    Content type: Research Published on:

  6. Implanted neural interfaces are electronic devices that stimulate or record from neurons with the purpose of improving the quality of life of people who suffer from neural injury or disease. Devices have been ...

    Authors: Ashley N. Dalrymple, Sonny T. Jones, James B. Fallon, Robert K. Shepherd and Douglas J. Weber
    Citation: Bioelectronic Medicine 2025 11:6
    Content type: Review Published on:

  7. Following the COVID-19 pandemic, there are many chronically ill Long COVID (LC) patients with different symptoms of varying degrees of severity. The pathological pathways of LC remain unclear until recently an...

    Authors: Marco Leitzke, Donald Troy Roach, Swen Hesse, Peter Schönknecht, Georg-Alexander Becker, Michael Rullmann, Bernhardt Sattler and Osama Sabri
    Citation: Bioelectronic Medicine 2025 11:5
    Content type: Review Published on:

  8. The octopus has many features that make it advantageous for revealing principles of motor circuits and control and predicting behavior. Here, an array of carbon electrodes providing single-unit electrophysiolo...

    Authors: Nitish Satya Sai Gedela, Ryan D. Radawiec, Sachin Salim, Julianna Richie, Cynthia Chestek, Anne Draelos and Galit Pelled
    Citation: Bioelectronic Medicine 2025 11:4
    Content type: Research Published on:

  10. In glioblastoma (GBM) therapy research, tumour treating fields by the company Novocureâ„¢, have shown promise for increasing patient overall survival. When used with the chemotherapeutic agent temozolomide, they...

    Authors: Isobel Jobson, Nguyen T. N. Vo, Edward Kujawinski, Chris Denning, Snow Stolnik, Veeren M. Chauhan and Frankie Rawson
    Citation: Bioelectronic Medicine 2025 11:2
    Content type: Research Published on:

  11. The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulatio...

    Authors: Imanuel Lerman, Yifeng Bu, Rahul Singh, Harold A. Silverman, Anuj Bhardwaj, Alex J. Mann, Alik Widge, Joseph Palin, Christopher Puleo and Hubert Lim
    Citation: Bioelectronic Medicine 2025 11:1
    Content type: Mini Review Published on:

  12. Current inflammatory bowel disease (IBD) treatments often fail to achieve lasting remission and have adverse effects. Vagus nerve stimulation (VNS) offers a promising therapy due to its anti-inflammatory effec...

    Authors: Fatemeh Hesampour, Diane M Tshikudi, Charles N Bernstein and Jean-Eric Ghia
    Citation: Bioelectronic Medicine 2024 10:29
    Content type: Research Published on:

  13. Drug-resistant hypertension affects approximately 9–18% of the United States hypertensive population. Recognized as hypertension that is resistant to three or more medications, drug-resistant hypertension can ...

    Authors: Garrett W. Thrash, Elijah Wang, Yifei Sun, Harrison C. Walker, Prasad Shirvalkar, Bryan K. Becker and Marshall T. Holland
    Citation: Bioelectronic Medicine 2024 10:28
    Content type: Review Published on:

  14. The purpose of this study was to investigate the effects of different electrical stimulation methods (bilateral electroacupuncture (BEA), unilateral EA (UEA), transcutaneous electrical acustimulation (TEA, sti...

    Authors: Md Jahangir Alam, Tingting Zhao, John W. Wiley and Jiande D. Z. Chen
    Citation: Bioelectronic Medicine 2024 10:27
    Content type: Research Published on:

  15. The protective effects of time spent outdoors emphasize the major role of daylight in myopia. Based on the pathophysiology of myopia, the impact of blue light stimulation on the signaling cascade, from melanop...

    Authors: Ana Amorim-de-Sousa, Ranjay Chakraborty, Michael J. Collins, Paulo Fernandes, José González‑Méijome, Jens Hannibal, Hosein Hoseini-Yazdi, Scott A. Read, Jens Ellrich and Tim Schilling
    Citation: Bioelectronic Medicine 2024 10:26
    Content type: Mini Review Published on:

  16. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention that shows promise as a potential treatment for depression. However, the clinical efficacy of tDCS varies, possib...

    Authors: Alejandro Albizu, Aprinda Indahlastari, Paulo Suen, Ziqian Huang, Jori L. Waner, Skylar E. Stolte, Ruogu Fang, Andre R. Brunoni and Adam J. Woods
    Citation: Bioelectronic Medicine 2024 10:25
    Content type: Research Published on:

  17. Integrating advanced machine-learning (ML) algorithms into clinical practice is challenging and requires interdisciplinary collaboration to develop transparent, interpretable, and ethically sound clinical deci...

    Authors: Khoa Nguyen, Debbie L. Wilson, Julie Diiulio, Bradley Hall, Laura Militello, Walid F. Gellad, Christopher A. Harle, Motomori Lewis, Siegfried Schmidt, Eric I. Rosenberg, Danielle Nelson, Xing He, Yonghui Wu, Jiang Bian, Stephanie A. S. Staras, Adam J. Gordon…
    Citation: Bioelectronic Medicine 2024 10:24
    Content type: Methodology Published on:

  18. Virtual Reality (VR) is an emerging technology in post stroke recovery. However, its precise role in stroke rehabilitation is not well defined. The aim of this paper is to conduct an overview of systematic rev...

    Authors: Ammar Khan, Yahia Z. Imam, Mohamed Muneer, Salman Al Jerdi and Sumanjit K. Gill
    Citation: Bioelectronic Medicine 2024 10:23
    Content type: Review Published on:

  19. The identification of acute cardioprotective strategies against myocardial ischemia/reperfusion (I/R) injury that can be applied in the catheterization room is currently an unmet clinical need and several inte...

    Authors: Giuseppe Giannino, Lorenzo Nocera, Maria Andolfatto, Valentina Braia, Federico Giacobbe, Francesco Bruno, Andrea Saglietto, Filippo Angelini, Ovidio De Filippo, Fabrizio D’Ascenzo, Gaetano Maria De Ferrari and Veronica Dusi
    Citation: Bioelectronic Medicine 2024 10:22
    Content type: Review Published on:

  20. Nearly all geriatric surgical complications are studied in the context of a single organ system, e.g., cardiac complications and the heart; delirium and the brain; infections and the immune system. Yet, we kno...

    Authors: Leah Acker, Kevin Xu and J. P. Ginsberg
    Citation: Bioelectronic Medicine 2024 10:21
    Content type: Hypothesis Published on:

  21. Peripheral neural interfaces facilitate bidirectional communication between the nervous system and external devices, enabling precise control for prosthetic limbs, sensory feedback systems, and therapeutic int...

    Authors: Alice Giannotti, Ranieri Santanché, Ciro Zinno, Jacopo Carpaneto, Silvestro Micera and Eugenio Redolfi Riva
    Citation: Bioelectronic Medicine 2024 10:20
    Content type: Research Published on:

  22. Bioelectronic Medicine (BEM), which uses implantable electronic medical devices to interface with electrically active tissues, aspires to revolutionize the way we understand and fight disease. By leveraging kn...

    Authors: Dimitrios A. Koutsouras, George G. Malliaras and Geert Langereis
    Citation: Bioelectronic Medicine 2024 10:19
    Content type: Perspective Published on:

  23. Authors: Danny V. Lam, Justin Chin, Meagan K. Brucker-Hahn, Megan Settell, Ben Romanauski, Nishant Verma, Aniruddha Upadhye, Ashlesha Deshmukh, Aaron Skubal, Yuichiro Nishiyama, Jian Hao, J. Luis Lujan, Simeng Zhang, Bruce Knudsen, Stephan Blanz, Scott F. Lempka…
    Citation: Bioelectronic Medicine 2024 10:18
    Content type: Correction Published on:

    The original article was published in Bioelectronic Medicine 2024 10:17

  24. Spinal cord stimulation (SCS) has demonstrated multiple benefits in treating chronic pain and other clinical disorders related to sensorimotor dysfunctions. However, the underlying mechanisms are still not ful...

    Authors: Danny V. Lam, Justin Chin, Meagan K. Brucker-Hahn, Megan Settell, Ben Romanauski, Nishant Verma, Aniruddha Upadhye, Ashlesha Deshmukh, Aaron Skubal, Yuichiro Nishiyama, Jian Hao, J. Luis Lujan, Simeng Zhang, Bruce Knudsen, Stephan Blanz, Scott F. Lempka…
    Citation: Bioelectronic Medicine 2024 10:17
    Content type: Research article Published on:

    The Correction to this article has been published in Bioelectronic Medicine 2024 10:18

  25. Implantable vagus nerve stimulation is a promising approach for restoring autonomic cardiovascular functions after heart transplantation. For successful treatment a system should have multiple electrodes to de...

    Authors: Fangqi Liu, Maryam Habibollahi, Yu Wu, Nazanin Neshatvar, Jiaxing Zhang, Ciro Zinno, Outman Akouissi, Fabio Bernini, Lisa Alibrandi, Khatia Gabisonia, Vincenzo Lionetti, Jacopo Carpaneto, Henry Lancashire, Dai Jiang, Silvestro Micera and Andreas Demosthenous
    Citation: Bioelectronic Medicine 2024 10:16
    Content type: Research article Published on:

  26. Vagus nerve stimulation (VNS) is an established therapy for treating a variety of chronic diseases, such as epilepsy, depression, obesity, and for stroke rehabilitation. However, lack of precision and side-eff...

    Authors: Antonin Berthon, Lorenz Wernisch, Myrta Stoukidi, Michael Thornton, Olivier Tessier-Lariviere, Pascal Fortier-Poisson, Jorin Mamen, Max Pinkney, Susannah Lee, Elvijs Sarkans, Luca Annecchino, Ben Appleton, Philip Garsed, Bret Patterson, Samuel Gonshaw, Matjaz Jakopec…
    Citation: Bioelectronic Medicine 2024 10:15
    Content type: Research article Published on:

  27. Blue light activates melanopsin, a photopigment that is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs). The axons of ipRGCs converge on the optic disc, which corresponds to the physi...

    Authors: Hosein Hoseini-Yazdi, Scott A. Read, Michael J. Collins, Hamed Bahmani, Jens Ellrich and Tim Schilling
    Citation: Bioelectronic Medicine 2024 10:13
    Content type: Research article Published on:

  28. Key to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune function. Sensory neurons (termed nociceptors) recognize harmful stimuli and...

    Authors: Aisling Tynan, Téa Tsaava, Manojkumar Gunasekaran, Carlos E. Bravo Iñiguez, Michael Brines, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Bioelectronic Medicine 2024 10:14
    Content type: Research article Published on:

  29. Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement,...

    Authors: Gerson N. Moreno Romero, Avery R. Twyman, Maria F. Bandres and Jacob Graves McPherson
    Citation: Bioelectronic Medicine 2024 10:12
    Content type: Mini-review Published on:

  31. Glioblastoma (GBM) presents as an aggressive brain cancer, notorious for its recurrence and resistance to conventional treatments. This study aimed to assess the efficacy of the EMulate Therapeutics Voyager®, ...

    Authors: Rajesh Mukthavaram, Pengfei Jiang, Sandra Pastorino, Natsuko Nomura, Feng Lin and Santosh Kesari
    Citation: Bioelectronic Medicine 2024 10:10
    Content type: Research article Published on:

  32. The vagus nerve has an anti-inflammatory effect through the inflammatory reflex, which inhibits the release of proinflammatory cytokines by macrophages. Recent pilot clinical trials, using implantable bioelect...

    Authors: Bruno Bonaz
    Citation: Bioelectronic Medicine 2024 10:9
    Content type: Commentary Published on:

    The original article was published in Bioelectronic Medicine 2024 10:8

  33. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint destruction. Neuroimmune modulation through electrical stimulation of...

    Authors: Daniel Peterson, Mark Van Poppel, Warren Boling, Perry Santos, Jason Schwalb, Howard Eisenberg, Ashesh Mehta, Heather Spader, James Botros, Frank D. Vrionis, Andrew Ko, P. David Adelson, Bradley Lega, Peter Konrad, Guillermo Calle, Fernando L. Vale…
    Citation: Bioelectronic Medicine 2024 10:8
    Content type: Research article Published on:

    The Commentary to this article has been published in Bioelectronic Medicine 2024 10:9

  34. Wireless power transfer (WPT) within the human body can enable long-lasting medical devices but poses notable challenges, including absorption by biological tissues and weak coupling between the transmitter (T...

    Authors: Sultan Mahmud, Ali Nezaratizadeh, Alfredo Bayu Satriya, Yong-Kyu Yoon, John S. Ho and Adam Khalifa
    Citation: Bioelectronic Medicine 2024 10:7
    Content type: Mini-review Published on:

  35. Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are importan...

    Authors: Gregory Girardi, Danielle Zumpano, Helen Raybould and Erkin Seker
    Citation: Bioelectronic Medicine 2024 10:3
    Content type: Research article Published on:

  36. Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in disc...

    Authors: Valentina Paggi, Florian Fallegger, Ludovic Serex, Olivier Rizzo, Katia Galan, Alice Giannotti, Ivan Furfaro, Ciro Zinno, Fabio Bernini, Silvestro Micera and Stéphanie P. Lacour
    Citation: Bioelectronic Medicine 2024 10:6
    Content type: Research article Published on:

  37. Seizure detection is challenging outside the clinical environment due to the lack of comfortable, reliable, and practical long-term neurophysiological monitoring devices. We developed a novel, discreet, unobst...

    Authors: McGregor Joyner, Sheng-Hsiou Hsu, Stephanie Martin, Jennifer Dwyer, Denise Fay Chen, Reza Sameni, Samuel H. Waters, Konstantin Borodin, Gari D. Clifford, Allan I. Levey, John Hixson, Daniel Winkel and Jonathan Berent
    Citation: Bioelectronic Medicine 2024 10:4
    Content type: Research article Published on:

  38. The effects of electromagnetic interference have been hiding in plain sight for millennia and are now being applied to the non-invasive stimulation of deep tissues. In the article by Missey et al., the effect ...

    Authors: Nigel Paul Pedersen and Raul Castillo Astorga
    Citation: Bioelectronic Medicine 2024 10:5
    Content type: Commentary Published on:

    The original article was published in Bioelectronic Medicine 2023 9:18

  39. Preclinical models of spinal cord stimulation (SCS) are lacking objective measurements to inform translationally applicable SCS parameters. The evoked compound action potential (ECAP) represents a measure of d...

    Authors: Eline M. Versantvoort, Birte E. Dietz, Dave Mugan, Quoc C. Vuong, Saimir Luli and Ilona Obara
    Citation: Bioelectronic Medicine 2024 10:2
    Content type: Research article Published on:

  40. Regaining motor function in individuals with cerebral palsy (CP) has been predominantly studied in children, resulting in an underrepresentation of adults in research efforts. We tested the efficacy of noninva...

    Authors: Rahul Sachdeva, Kristin Girshin, Yousef Shirkhani and Parag Gad
    Citation: Bioelectronic Medicine 2024 10:1
    Content type: Short report Published on:

  41. Efferent cholinergic signaling is a critical and targetable source of immunoregulation. The vagus nerve (VN) is the primary source of cholinergic signaling in the body, and partially innervates hepatic functio...

    Authors: Samuel Martínez-Meza, Bhavya Singh, Douglas F. Nixon, Nicholas Dopkins and Louie Mar A. Gangcuangco
    Citation: Bioelectronic Medicine 2023 9:29
    Content type: Mini-review Published on:

  42. Nearly 5 decades ago, the effect of trigeminal nerve stimulation (TNS) on cerebral blood flow was observed for the first time. This implication directly led to further investigations and TNS’ success as a ther...

    Authors: Keren Powell, Kanheng Lin, Willians Tambo, Andrea Palomo Saavedra, Daniel Sciubba, Yousef Al Abed and Chunyan Li
    Citation: Bioelectronic Medicine 2023 9:30
    Content type: Review Published on:

  43. The increasing prevalence of chronic diseases is a driver for emerging big data technologies for healthcare including digital platforms for data collection, systems for active patient engagement and education,...

    Authors: Dafni Carmina, Valentina Benfenati, Claudia Simonelli, Alessia Rotolo, Paola Cardano, Nicoletta Grovale, Lorenza Mangoni di S. Stefano, Tiziana de Santo, Roberto Zamboni, Vincenzo Palermo, Michele Muccini and Francesco De Seta
    Citation: Bioelectronic Medicine 2023 9:28
    Content type: Perspective Published on:

  44. The vagus nerve regulates inflammation and cytokine release through the inflammatory reflex. Recent pilot clinical trials using implantable bioelectronic devices have demonstrated the efficacy of vagus nerve s...

    Authors: Bruno Bonaz
    Citation: Bioelectronic Medicine 2023 9:26
    Content type: Commentary Published on:

    The Research article to this article has been published in Bioelectronic Medicine 2023 9:23

    The original article was published in Bioelectronic Medicine 2023 9:23

  46. Noninvasive ultrasound (US) has been used therapeutically for decades, with applications in tissue ablation, lithotripsy, and physical therapy. There is increasing evidence that low intensity US stimulation of...

    Authors: Claire R. W. Kaiser, Adam B. Tuma, Maryam Zebarjadi, Daniel P. Zachs, Anna J. Organ, Hubert H. Lim and Morgan N. Collins
    Citation: Bioelectronic Medicine 2023 9:25
    Content type: Research article Published on:

  47. Neuroinflammation is an important biological process induced by complex interactions between immune cells and neuronal cells in the central nervous system (CNS). Recent research on the bidirectional communicat...

    Authors: Hiroki Tanaka, Rie Hasebe, Kaoru Murakami, Toshiki Sugawara, Takeshi Yamasaki and Masaaki Murakami
    Citation: Bioelectronic Medicine 2023 9:24
    Content type: Review Published on:

  48. No effective treatment for NAION with strong evidence has been established till date. The aim of this investigator-led, prospective, non-randomized, open-label, uncontrolled multi-center exploratory clinical t...

    Authors: Gen Miura, Tadami Fujiwara, Yoshihito Ozawa, Yuki Shiko, Yohei Kawasaki, Tomohiro Nizawa, Tomoaki Tatsumi, Takuji Kurimoto, Sotaro Mori, Makoto Nakamura, Hideki Hanaoka, Takayuki Baba and Shuichi Yamamoto
    Citation: Bioelectronic Medicine 2023 9:22
    Content type: Short report Published on:

  49. Vagus nerve stimulation is an investigational anti-inflammatory therapy targeting the nervous system to modulate immune activity. This study evaluated the efficacy and safety of transcutaneous auricular VNS (t...

    Authors: Benjamin Sahn, Kristine Pascuma, Nina Kohn, Kevin J. Tracey and James F. Markowitz
    Citation: Bioelectronic Medicine 2023 9:23
    Content type: Research article Published on:

    The Commentary to this article has been published in Bioelectronic Medicine 2023 9:26

    The original article was published in Bioelectronic Medicine 2023 9:26

  50. The emerging field of bioelectronic medicine (BEM) is poised to make a significant impact on the treatment of several neurological and inflammatory disorders. With several BEM therapies being recently approved...

    Authors: Eric H. Chang, Arielle H. Gabalski, Tomas S. Huerta, Timir Datta-Chaudhuri, Theodoros P. Zanos, Stavros Zanos, Warren M. Grill, Kevin J. Tracey and Yousef Al-Abed
    Citation: Bioelectronic Medicine 2023 9:21
    Content type: Meeting report Published on:
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    Source Normalized Impact per Paper (SNIP): 0.817
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Bioelectronic Medicine

ISSN: 2332-8886